Ahh yes, my setup. 30 inch LCD (HP LP3065) and a 21 inch (Dell 2001FPW). Resolution, you ask? 2550x1600 and 1200x1600 respectively. Downsides? I gotta make my own wallpapers for the big screen. Some would think that having to move your head a bit while looking at stuff is annoying, but I don't mind. I move my head much more while I drive.
Every PC gamer, graphic designer or artist should get a setup like this. Really, it's visual nirvana (without going into 5 figures). Pictures don't do it justice.
I have it setup with winamp and trillian on the smaller screen so that I can have everything important on the main screen. No need to minimize, ever.
The tablet's in the drawer (in case you see the pen but wonder where the tablet is)
And yes, I'm a lefty that used the mouse with the left hand. A rare thing among lefties!
The black thing to the right is the amplifier for the sound system, and the little blue light below it is from the subwoofer (klipsch 12-incher, I highly recommend it)
Overkill for a PC? Definitely, but since I spend so much time in front of it, I figured it'd be stupid to skimp out on its quality.